Xifaxan^® (rifaximin) 550 mg
and Hepatic Encephalopathy

Hepatic encephalopathy (HE) causes mental and physical symptoms in people with liver disease (cirrhosis).
Xifaxan 550 mg may help reduce the risk of HE events and related symptoms.

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Hepatic Encephalopathy
patient resources

The Hepatic Encephalopathy Living Program (H.E.L.P.) offers a variety of patient resources to help you understand and manage your condition.

Request H.E.L.P.

Help with cost and insurance

Cost and insurance support is available, regardless of whether or not you have prescription coverage. Find out about the Xifaxan 550 mg Access Helpline, Instant Savings Card, and Patient Assistance Program.

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Resources and support
for caregivers

Taking care of a person living with hepatic encephalopathy can be challenging. But with helpful resources, tips, and advocacy groups, it can be a little easier.

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Get support materials

Help with insurance

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Reduce the risk of overt HE recurrence with Xifaxan

Xifaxan 550 mg is an antibiotic treatment for adults living with hepatic encephalopathy (HE)—a complication of liver disease (cirrhosis). Overt HE can affect the brain and result in a variety of mental and physical symptoms. Xifaxan 550 mg may prevent these symptoms from returning.

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Important Safety Information about XIFAXAN 550 mg

XIFAXAN^® (rifaximin) 550 mg tablets are not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin or any of the components in XIFAXAN.

XIFAXAN, like nearly all antibiotics, can alter the normal bacteria of the colon. This can lead to an overgrowth of Clostridium difficile (C. difficile) bacteria. If you take XIFAXAN, there is a chance you could experience diarrhea caused by C. difficile. C. difficile can cause symptoms ranging in severity from mild diarrhea to fatal colitis. If you suspect you have C. difficile–associated diarrhea, contact your healthcare provider immediately, as treatment may need to be discontinued.

XIFAXAN has not been studied in people with MELD scores over 25 and only 8.6% of people in the controlled study had MELD scores over 19. There is an increased chance that XIFAXAN will spread through your body if you have more severe hepatic dysfunction. Therefore, if you have severe hepatic impairment, which is a Child-Pugh score of C, you should talk to your healthcare provider before taking XIFAXAN.

If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN.

In the clinical study, the most common side effects associated with XIFAXAN 550 mg tablets—occurring in at least 10% of people receiving XIFAXAN—were peripheral edema (swelling, usually in the ankles or lower limbs), nausea (feeling sick to your stomach), dizziness, fatigue (feeling tired), and ascites (a buildup of fluid in the abdomen).

Xifaxan 550 mg is not available for sale outside the U.S.

Xifaxan 550 mg is licensed by Alfa Wassermann S.p.A. to Salix Pharmaceuticals, Inc.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-508-0024
Fax: 1-510-595-8183
Email: salix@medcomsol.com

Xifaxan® (rifaximin) 550 mg and Hepatic Encephalopathy

Hepatic Encephalopathypatient resources