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Physician resources

Salix is committed to helping physicians and patients effectively manage overt HE.

Read through the information below for more on Salix programs, education opportunities, and links.

• Video: National experts present "Evolving Overt HE Therapy: Xifaxan550 for Reducing the Risk of Breakthrough Episodes"
• The Hepatic Encephalopathy Living Program
• Patient Savings Information
• The HE Symptom Tracker
• Reimbursement support
• Medical liaison support

Evolving Overt HE Therapy: Xifaxan550 for Reducing the Risk of Breakthrough Episodes

Watch national hepatology experts give their perspective as they each present "Evolving Overt HE Therapy: Xifaxan550 for Reducing the Risk of Breakthrough Episodes." This interactive presentation details the efficacy of Xifaxan 550 mg in reducing the risk of overt HE recurrence in patients 18 and older.

Please select a speaker below.

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The Hepatic Encephalopathy Living Program

Salix is committed to helping HE healthcare providers and their patients (≥18 years of age) effectively address the complexities of overt HE management through H.E.L.P. —the Hepatic Encephalopathy Living Program.

Benefits include:

• A 24-hour, toll-free hotline to answer patients’ product-related questions
• Patient co-pay assistance
• Patient education materials
• Treatment adherence support

Click to watch the video below and discover all the unique benefits that H.E.L.P. brings to both patients and healthcare providers.

To join, fill out the H.E.L.P. enrollment form or call 1-866-XIFAXAN (943-2926).

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Patient Savings Information

Salix Pharmaceuticals offers a co-pay card to help eligible patients* save up to $100 per month on their Xifaxan 550 mg prescription.

Eligible patients* can

• Receive their Xifaxan550 Savings Card directly from their physician when Xifaxan 550 mg is prescribed
• Go to www.xifaxan550.com to print out or activate a card

*Xifaxan550 Savings Card is not available for residents of MA or patients whose prescription plan is paid/partially paid by Medicaid, Medicare, or federal or state government programs. VOID where prohibited by law.

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The HE Symptom Tracker

Help your patients and their caregivers identify the signs
of an HE flare-up. Xifaxan 550 mg offers an easy-to-use
HE Symptom Tracker (PDF) that may help your patients recognize the mental and physical symptoms of overt HE and alert you before their condition worsens. Overt hepatic encephalopathy is a serious condition, but with proper management it may be controlled.

The HE Symptom Tracker is also available for your patients or their caregivers to download directly from the Xifaxan 550 mg patient Web site.

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Reimbursement support

3-Step Xifaxan 550 mg reimbursement:

Step 1: Download and fill out the Patient Information Form

To download the form in Word (.doc) format, click here

For instructions on how to fill out the form, click here

Step 2: Call 1-866-XIFAXAN (943-2926) to connect to the Xifaxan 550 mg Reimbursement Helpline.

This free support service connects your office and patients to trained reimbursement analysts to answer questions you may have, and to help negotiate appeals should your patients’ claims be denied. Open Monday–Friday, 8:30 am–5:30 pm EST.

The helpline can also provide a timely solution to address issues you may encounter, including:

• Receiving current reimbursement policies for private payers, Medicaid, and Medicare
• Verifying individual patient coverage
• Verifying insurance coverage associated with the patient assistance program
• Assisting with prior authorizations
• Managing negotiation of appeals on denied claims
• Receiving customized information to assist with coverage or appeals

Step 3: Submit your completed Patient Information Form to the Xifaxan 550 mg Reimbursement Fax Line 1-800-387-5807

If you would like a sales representative to discuss our Rebate Card Program with you, please call us at 1-866-669-SLXP (7597).

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Medical liaison support

Salix provides a team of medical experts and liaisons for its physician customers. If you still have questions about Xifaxan 550 mg that have not been answered on this Web site, please call us at 1-866-669-SLXP (7597).

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IMPORTANT SAFETY INFORMATION

XIFAXAN 550 mg is indicated for reduction in risk of overt hepatic encephalopathy (HE) recurrence in patients ≥18 years of age. In the trials of XIFAXAN for HE, 91% of the patients were using lactulose concomitantly. XIFAXAN has not been studied in patients with MELD scores >25, and only 8.6% of patients in the controlled trial had MELD scores over 19. There is increased systemic exposure in patients with more severe hepatic dysfunction. Therefore, caution should be exercised when administering XIFAXAN to patients with severe hepatic impairment (Child-Pugh C).

XIFAXAN is contraindicated in patients with a hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN. Hypersensitivity reactions have included exfoliative dermatitis, angioneurotic edema, and anaphylaxis.

Clostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including XIFAXAN, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon which may lead to overgrowth of C. difficile. If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued.

The most common adverse reactions occurring in >8% of patients in the clinical study were edema peripheral (15%), nausea (14%), dizziness (13%), fatigue (12%), ascites (11%), muscle spasms (9%), pruritus (9%), and abdominal pain (9%).

Xifaxan550 is not available for sale outside the U.S.
Xifaxan550 is licensed by Alfa Wassermann S.p.A. to Salix Pharmaceuticals, Inc.

Complete Prescribing Information.

You are encouraged to report negative side effects to the FDA. Visit www.fda.gov/safety/medwatch/ or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:
Salix Product Information Call Center
Phone: 1-800-508-0024
Fax: 1-510-595-8183
E-mail: Salix@medcomsol.com